Butea superba Summary (All / effects / data and information)

Butea superba
Summary (All / effects / data and information is essential benefits)
Butea Superba plant is a tuber that is clearly similar to Pueraria still seems to be the opposite in fact. This tuber has been used traditionally to improve the vitality of male and as an aphrodisiac in Thailand and that seems to be the source of the compounds of masculinity.

When examined the effects of masculinity studies, there seems to be the classic signs of the direct activation of androgen (in particular, an increase in liver enzymes in some studies and the growth of the sexual organs of male, a decrease in testosterone levels of serum was observed possibly due to negative feedback), but unlike his sister grass (Pueraria) that mediate these effects are biologically active masculinity is not currently known, nor is its powers with respect to known testosterone.

It seems that low doses of Butea Superba to be safe for human consumption, on the basis of limited evidence, although that is connected to the higher doses of the mutations in mice (300-1000mg / kg, which is the human equivalent of 48 mg / kg or higher) and on this as they are undesirable.

It seems that both studies erectogenic Butea Superba and its effects have flaws, and in spite of this herb could potentially be helpful erectogenic at this time does not appear to.



What You Should Know
Also known as

Red Kwao Krua


Not to be confused with

White Kwao Krua (Pueraria), Butea monosperma


Things to consider

Maybe androgen, thus making many similar testosterone levels to the highest risk
Taking (the recommended dose, active and quantities, and other details)
There is insufficient information to recommend supplements butea superba, but it seems that is commonly used in the range of 100-250mg. Biologically active and latent minute behind its effects are not known
Butea Superba is one of the three herbs with a label "Kwao Krua" in the traditional Thai medicine and more specifically called "Red Kwao Krua" with other relevant herbs that "white" Kwao Krua (Pueraria) and "black 'Kwao Krua (Moukonh collettii); Butea Superba is similar to visually Pueraria. [1]

Butea Superba is a plant tubers that have been used for the purposes of male life in Thailand

1.2. Installation

Butesuperin A and B [2]
Medicarpin, [3] as found in Butea monosperma
Formononetin and Prunetin (isoflavones) [3]
methoxyflavone and 3,7,3 'Trihydroxy 4' glucoside [4]
3,5,7,3 ', 4'-pentahydroxy-8- methoxy-glucoside and flavonol [5]
Isoflavones genistein and daidzein and coumestrol [2]
PROCYANIDIN B2 and B5, as well as the constituent (-) - Abakatchen [6]
It is known that some of the components, but the currently active component does not know


2. Pharmacy

21. enzyme reactions

3,7,3'Trihydroxy 4 'methoxyflavone seems to be Vosfodestraz camp inhibitor with IC50 of 190ug / ml (glucoside and has a presence IC50 value of 58ug / ml), which exceed those theophylline active controls (615ug / ml), and caffeine (420ug / ml). [4]



3. Neuroscience

3.1. Acetylcholine

In a study for the detection of Thai herbs, Butea Superba 0.1 mg / ml was able to curb acetylcholineasterase in the range of 50-65%, performed with respect to Tabernaemontana suberosa divaricata and Stephania. All herbs relative poor performance of galantamine as the active control [7].

Can inhibit acetylcholinesterase (acetylcholine and increase the response), but below the level for other herbs, as well as active control of galantamine


4. interactions organs of the body

4.1. Rod

Butea Superba has been observed to improve the erection of the penis in mice focus 0.1-1000mg / ml (in vitro tests in the penis rat tissues), where the average pressure cavernous to 0.1 mg / ml (1.7%) 0.1 mg / ml (6.8%), and 10 mg / ml (4.2%) and 1000 mg / ml (8.3%); after a little concentration dependence. [8] Pressure measuring intracavernous (ICP), correlated concentration with 1 mg / kg as was seen most effective, and relaxing effect of Butea Superba seemed enhanced when incubated with the compound (one molecule of small banners is the result of the inhibition of PDE5). [8] The erection of the penis has been copied this feature in diabetic rats (diabetes tends to impede the function of secondary erection of poor circulation) with 10 mg / kg of ethanol extract being the most effective dose (relative to 1 mg / kg and 100 mg / kg, in spite of all they are better than control) [9] In spite of the reported study once in a power greater than Viagra, they can not repeat these effects. [10]

/ Ml in the laboratory extraction of ethanol from Butea Superba stem 50 micrograms to prevent ROCK-II of 51.83%, with aqueous extract inhibition respectively 34.85% has been shown, [11] these herbs exceeded and spherical flowers INDEX (22.4% and 36.77%, respectively), Chlorophytum borivilianum (4.11% and 40.54%) and terrestris (20.48% and 10.83%), but below the level to a large extent to the proportion of Syzygium cumini (87.27% and 89.67%) and Terminalia chebula (87.55% and 86.83%). [Eleven]

It has to induce relaxation of the penis mechanisms
A study of people who suffer from erectile dysfunction using basic tuber extract 500MG for three months there has been an improvement in sexual function, as reported by the IIEF-5 with 82.4% of patients (n = 17 total) reporting either fair or excellent basis for improvement. [12] This study is very limited, if not reduced in importance, and the pilot double-blind, placebo as a condition of all withdrew. [12]

In an open forum for people taking 100 mg of Butea Superba proerectile be noted that the effects of the herb, when taken 1-2 hours before sex, and comparable to the active control trial to Viagra. When examining the double blind manner using a lot of different Butea Superba, these effects failed to be replicated implementation. Note [10] The book is larger than the variation between batches deal, and said that this combination of PDE5 inhibitors in the first batch cause false positive. [10]

Preliminary evidence to support the use of Butea Superba for use of erectile dysfunction, but literally learns placebo group withdrew from the first and second study seems to have used the product defect (with the results even less impressive coming a lot more below)

4.2. Man reprodutive bodies

When Butea Superba male rats fed daily for 8 weeks (2 mg / kg 0.25 mg / kg, and 250 mg / kg and 1250 mg / kg) pointed out that the sperm count increased about 16% in all doses notice any dependency dose , and although it seems that there is a tendency to gain weight just TESTE 1250 mg / kg group and the arrival of importance. [13]



5. interact with hormones

5.1. Testosterone

I assumed one of the studies that Butea Superba has implications masculinity directly, as evidenced by the 150-200 / kg of the powder root causing the low a dose-dependent in testosterone serum and along with the side effects normally associated with reminders (increased serum alkaline phosphatase and AST, and increase the weight of the spleen). [14] These effects restores masculinity in female mice. [fifteen]

Limited evidence to support that, but there is some evidence to suggest that elements of Butea Superba has masculinity direct action
In mice, Butea Superba in oral doses of 10, 50 or 250 mg / kg daily for 8 weeks failed to influence the circulating testosterone levels [16], although another study found a dose reduction depends above 250 mg / kg . [14] When tested in humans, in a sample of people who suffer from erectile dysfunction increased from 2.751.40ng / mg to 3.061.37ng / mg (11.2%) was observed, but is not considered statistically significant. [12]

She noted at least one case study in hyperandrogenemia case related supplements Butea Superba, where a man 35 years Butea Superba took (dose undeclared) of 'weeks for the purpose of hair growth and after clinical examination in DHT serum and 1512 pg / ml (152% of the maximum possible value on average Natural), 328ug / ml DHEAS, and 1.7% of free testosterone and 43.24 pg / ml SHBG. [17] and after the cessation of grass, DHT and libido natural track in 1 week.

Highly reliable effects on circulating with low testosterone (believed to be secondary to androgen plant nutrients) and increase (unknown reason) both reports

5.2. Estrogen

One study reported that there are some weak phytoestrogens (isoflavones and pterocarpan one) Butea Superba content with the relative strength (relative to 17β-estradiol) ranging from 5.27 to 15.5%. It seems [18] Other components (not currently known) in extracts of Butea Superba that have anti-estrogenic effects against 17β-estradiol when coincubated. [18]

Potential estrogenic and anti-estrogenic effects depending on the cellular context, the importance of the process do not know

5.3. Hormone

In male rats showed, either sexual testicles intact or without (orchidectomized) to 50 and 250 mg / kg (10 mg / kg) is able to suppress an increase in the hormone (LH) associated with the removal of the testicles; there was no significant effect on the sound mice. [16]



6. Safety and Toxicity

6.1. Public

Oral intake 1250 mg / kg of tuber to rats for a period of 8 weeks stop toxic effects, [13] despite the fact that this same study indicates Bulletin (can not determine the original paper site) at 360 mg injection / kg was lethal during heart failure. [13] which is equivalent to Thailand FDA seems to have established a safe limit of these food products 100 mg per day or 0.2 mg per 100 g of body weight (50 kg 100 mg / £ 110 l). [13]

It has been observed that high doses of Butea Superba consumption (300 mg / kg in mice, dose human than 48 mg / kg) can lead to genotoxic effects in spite of less than free of toxic doses and [19] This observed elsewhere with 1000 mg / kg. But not 200 mg / kg. [20]