Saw Palmetto I saw it praised the Palmetto mixture of repens

Saw Palmetto
I saw it praised the Palmetto mixture of repens fatty from creeping acids for its ability to increase testosterone (ineffective) and suppress the growth of prostate (effectiveness is questionable); it was safe to use in benign prostatic hyperplasia and rates of flow of urine is normal in men, but studies have conflicting results of in terms of efficiency.

Saw Palmetto is a supplement that is derived from the fruit of the saw palmetto plant. Supplement (Palmetto) has a caloric value, because it is a combination of fatty acids.

Fatty acids in question have the ability to prevent the enzyme that converts testosterone to dihydrotestosterone (DHT), the latter of which is more androgenic, and can cause hair loss in genetically susceptible.

Is used for its effects on the production of DHT also resulted in saw palmetto for benign prostatic hyperplasia (BPH), and lower urinary tract symptoms (LUTS) in men. Some studies have shown positive results, but brought the largest and most well-designed studies to be effective in question.



What You Should Know
Also known as

Creeping repens
Taking (the recommended dose, active and quantities, and other details)
While the active compound (s) is not yet known, it is known to exist in what is known as breakage "liposterolic" of fruit. If the use of saw palmetto to choose the product that discloses the percentage of extension that this break.

Saw palmetto supplements tends to be in the range of 160-320 mg, once a day, for a product is 80-90% by weight of vehicles liposterolic. Although it was not confirmed whether the needs of saw palmetto taken with food because of the nature of the insoluble fraction of this is advised.

1.1. Origin and installation

'Saw palmetto "refers to the creeping raspberry repens known as saw palmetto traditionally used for male fertility and sexual desire and claimed to increase breast size in women. [4]

The fruits of saw palmetto, referred to SRM 3250, [5] have the following composition:

Two biologically active fatty acids Home (see the rest of the full summary for more details): (Z) -9-octadecenoic acid (C18: 1N-9) (oleic acid) block 3.24 ± 0.15% in the dry acid triglyceride and 33.7 ± 1.9 mg / g dry weight of free fatty acids, and dodecanoic (C12: 0) (lauric acid) 2.962 ± 0.062% of the dry weight as triglycerides and 7, 21 ± 0.036mg / g dry weight of free fatty acids as [6]
Octanoic acid (C8: 0) (caprylic acid): FFA dry mass as 0.1072 ± 0.0027% and 0.781 ± trigycerides 0.036mg / g dry weight [6]
Decanoic acid (C10: 0) (capric): 0.1175 ± 0.0055% dry mass as acid triglycerides [6]
Tridecanoic acid (C13: 0): dry mass as 0.0076 ± 0.0014% and 0.0165 fatty acids trglycerides ± 0.0011mg / g dry mass as free [6]
FFA 1.103 ± 0.007% dry mass as triglycerides and 5.96 ± 0.21mg / g dry weight [6]: tetradecanoic acid (C14: 0) (Myristic acid)
Pentadecanoic acid (C15: 0): 0.0047 ± 0.0006% dried mass as triglycerides and fatty acids 0.0121 ± 0.0009mg / g dry weight Free [6]
FFA 0.869 ± 0.027% dry mass as triglycerides and 8.72 ± 0.45mg / g dry weight [6]: hexadecanoic acid (C16: 0) (palmitic acid)
(Z) -9-hexadecenoic acid (C16: 1N-7) (Albalmtewolak acid): 0.0158 ± 0.0010% dried mass as triglycerides and 0.216 ± 0.014mg / g dry weight of free fatty acids as [6]
Heptadecanoic acid (C17: 0): 0.0061% dry mass ± 0.0007 0.0926 ± triglycerides and 0.0060 mg / g free fatty acids as [6]
Stearic acid (C18: 0): 0.1791 ± 0.0054% dry mass as triglycerides and fatty acids 2.023 g ± 0.094mg / free [6] (stearic acid)
(Z) -11-octadecenoic acid (C18: 1N-7) (acid vaccenic): 0.0547 ± 0.0030% dried mass as triglycerides and 0.789 ± 0.053mg / g dry weight of free fatty acids as [6]
(Z, Z) acid 9,12-octadecadienoic (C18: 2N-6) (linoleic acid): 0.824 ± 0.055% dry mass as triglycerides and 5.70 ± 0.48mg / g dry weight of free fatty acids as [6]
(Z, Z, Z) -9,12,15 acid-octadecatrienoic (C18: 3 n 3) (linolenic acid): 0.194 ± 0.025% dry mass as triglycerides and fatty acids 1.351 g ± 0.050mg / free [6] Acid -Eicosanoic (C20: 0) (acid peanuts): FFA dry mass% 0.0097 ± 0.0002 0.1455 ± triglycerides and 0.0076 mg / mg dry mass [6] - (Z) -11 eicosenoic acid (C20: 1N-9) ( Acid gondoic): 0.0173 ± 0.0006% dry mass as triglycerides [6] acid -Docosanoic (C22: 0) (behenic) acid: 0 dry mass, 0.0002% ± 0066 as triglycerides and 0.0564 ± 0.0050mg / g fatty acids dry free mass in terms of [6] acid -Tetracosanoic (C24: 0) (lignoceric acid) dry weight 0.0107 ± 0.0003% and triglycerides 0.0960 ± 0.0033mg / g free fatty acids as [6]
Campesterol (a phytosterol) to 0.1175 ± 0.0025mg / g dry weight [6]
β- sitosterol (a phytosterol) to 0.454 ± 0.018mg / g dry weight [6]
Stigmasterol (a phytosterol) to 0.0477 ± 0.0020mg / g dry weight [6]
In general, most of the saw palmetto fatty acids present as triglycerides in the form of free fatty acids. [6]

Saw palmetto contains many fatty acids, mainly in triglycerides, and phytosterols form.
The mechanism of action that saw palmetto is known for its inhibition of the enzyme 5α reductase, which is responsible for converting testosterone to the more androgenic form, dihydrotestosterone (DHT). Anti-5 α reductase is fat soluble extracts of fruits, [7] with more power in the thigh saponificable. [7]

Saw palmetto vital activity tends to focus on components that are fat-soluble of berries.

1.2. Formulations and variables

Supercritical CO2 extract of saw palmetto, also known under the brand name Sabalselect®, tend to have a high proportion of unsaturated fatty acids (84%) with less than esters of fatty acids amounts (10%) and less than 2% of other chemical components ( phytosterols, aliphatic alcohols, and vehicles polypyrenic). [8] Sabalselect® similar to the National Institute of Standards and Technology reference material SRM 3251, which is extracted using a similar procedure. [5]

This extraction process increases the amount of fatty acids as triglycerides on the ground fruit (6-25 times [5]), consisting mostly of unsaturated fatty acids lauric (aka. Dodecanoic) and oleic acid with some palmitic acid Almirastic major components of acid next. [8] [9] [5]

This conclusion, in particular, in contrast to the raw berries, certified and concentrations of phytosterols (campesterol, β- sitosterol and stigmasterol), carotenoids (46.8μg / g as β-carotene), vitamin E vitamers (gamma-tocopherol and delta in 280μg / g 35.3μg g /) . [5]

Excerpts supercritical CO2 is one of the basic forms of saw palmetto extracts.
Another is known as a fatty extract Permixon® hexane extract n / sterols extract of the fruit. [10]

Known as the extract IDS 89 (Strogen®) capable of 5α reductase inhibition in vitro with IC50 of 2,200μg / ml when assayed in the mixture entire prostate, while having some effectiveness in 500μg / ml in all epithelial cells and prostate tissue. [7] found this excerpt to be non-competitive inhibitor. [7]